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It is found in the Green Thumb Tab and rrquires a Living Log and a Venom Gland to craft. This also permanently removes the Poisonous Hole. The Poison Balm is a character-exclusive item craftable only by Wormwood in the Don't Starve: Hamlet DLC. If timed correctly (immediately after the poison cloud animation) the player can dig up the hole without getting poisoned. Poisonous Holes can be dug up with a Shovel for a 50% chance at Venom Glands.This method removes the chance of being poisoned while fighting venomous creatures, and gives the player multiple glands that can be kept on hand for crafting Anti Venom.

The Sea Hounds will kill most, if not all, of the Stink Rays, and when the player returns, they will find multiple Venom Glands floating in the ocean.

One of the safest and most efficient ways to farm Venom Glands is by luring Sea Hounds into a group of Stink Rays and then leaving.

Consuming the Venom Gland while having less than 5 health will not increase the health. If the player character has less than 80 health left, Venom Gland will only deal enough damage, if at all, to reduce the remaining health to a minimum of 5. Consuming a Venom Gland to cure poison deals up to 75 poison damage, however this damage will not kill the player character. Venom Glands can also be directly consumed to cure the poison effect. It is used for crafting items such as the Anti Venom, as well as poisoned weapons.

Eating Poison Dartfrog Legs or Tubers while wearing Seashell Suit or Horned Helmet won't poison the player.A Venom Gland is a healing item from the Shipwrecked DLC.

The total poison damage is 289.54 over 3 days, which can kill any Character without healing.

Regardless of being immune to poison damage, WX-78 still gets a visual effect from being poisoned.

Before the Seas the Day update, characters would remain poisoned indefinitely until an Anti Venom was applied.

Prior to the Hang Ten update, food drops from poisoned mobs lost all their freshness instantly, making them Rot.

Out of the six poisonous creatures, only the poisonous Spider Warrior and Scorpion can be inflicted with Poison.

Besides, there are also three new ways to cure poison: Giving treasures to the Wishing Well, eating Magic Water and using Poison Balm which is exclusive to Wormwood. There are two new ways to get poisoned: Eating poisonous Food such as a Tuber and being attacked by a Scorpion with its sting. The Hamlet DLC also includes this mechanic. Poison lasts 120 seconds for Mobs, after which the poison will wear off. It should be taken into account that upon a poisoned creature dying, all food items will instead be dropped at half freshness making them stale on drop.

Some Mobs are naturally immune to poison. Poison can also affect Mobs, which reduces their damage and movement speed by 25%, and increases their attack period by 25% (in other words, they attack 20% less frequently). WX-78 is immune to poison, therefore they do not require additional protection. When fighting poisonous enemies, wearing a Seashell Suit or a Horned Helmet will prevent poisoning through physical contact, and wearing a Particulate Purifier will prevent poisoning through gas attacks. Following table describes the increase of the poison effect over time: While poisoned, player characters will gain a -0.2 hunger drain modifier, meaning characters with default hunger drain will get hungry 20% slower. The sanity is lost at a rate of 6 per minute, and will not increase over time. As the damage increases, the poison effect in the UI will become more pronounced. Over the next 2 days, poison will deal increasing amounts of damage, and more frequently. Initially, poison will deal 1 damage every 10 seconds for the duration of a day. The effect of poisoning will progressively worsen over time. If the player character has less than 80 health, the damage of the gland is reduced to leave 5 health after consumption. Poison can also be cured by using a Venom Gland, however, the gland will deal up to 75 poison damage when used, but it will not kill the player character. The effects of poison can be cured by consuming an Anti Venom. The poison will wear off after 3 game days. When a character is poisoned, they will slowly lose health and sanity. If a player Character is hit by a Mob or an environmental hazard that has a naturally poisonous attack they will become poisoned. Poison is a new mechanic found in the Shipwrecked DLC.